I denne moderne version af historien om den legendariske detektiv er Sherlock Holmes en tidligere narkoman som starter et nyt liv i New York som konsulent for politiet. Ved hans side er hans tro følgesvend, Dr. Joan Watson.

Episoder
01: Pilot
02: While You Were Sleeping
03: Child Predator
04: The Rat Race
05: Lesser Evils
06: Flight Risk
07: One Way to Get Off
08: The Long Fuse
09: You Do It to Yourself
10: The Leviathan
11: Dirty Laundry
12: M.
13: The Red Team
14: The Deductionist
15: A Giant Gun, Filled with Drugs
16: Details
17: Possibility Two
18: Déjà Vu All Over Again
19: Snow Angels
20: Dead Man's Switch
21: A Landmark Story
22: Risk Management
23: The Woman
24: Heroine